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LRBA and CTLA. en Model depicting the regulation of CTLA vesicle trafficking by LRBA Patients with LRBA deficiency show CTLA loss and immune dysregulation responsive to abatacept therapy Science doi aaa Lo Zhang Lu Zheng Zhang Kanellopoulou Zhang Liu Fritz Marsh Husami Kissell Nortman Chaturvedi Haines Young Mo Filipovich